Is 6 mercaptopurine an immunosuppressant?


Is mercaptopurine an immunosuppressant?

Azathioprine and mercaptopurine are immunosuppressants. The immune system is important for fighting infections, but sometimes cells in the immune system attack the body’s own tissues and trigger inflammation like that in Crohn’s and Colitis.

Does mercaptopurine weaken the immune system?

MERCAPTOPURINE, 6-MP (mer kap toe PYOOR een) is a chemotherapy drug. It interferes with the growth of cancer cells and can reduce immune system activity.

What type of drug is 6 mercaptopurine?

Mercaptopurine is in a class of medications called purine antagonists. It works by stopping the growth of cancer cells.

Is purinethol an immunosuppressant?

Mercaptopurine is immunosuppressive and may impair the immune response to infectious agents or vaccines. Due to the immunosuppression associated with maintenance chemotherapy for ALL, response to all vaccines may be diminished and there is a risk of infection with live virus vaccines.

How long can you stay on mercaptopurine?

Research suggests that for some people azathioprine or mercaptopurine can continue to be effective for at least five years and possibly longer.

What happens when you stop taking mercaptopurine?

While you are being treated with mercaptopurine, and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor’s approval. Mercaptopurine may lower your body’s resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent.

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Is mercaptopurine a chemotherapy?

Mercaptopurine is a chemotherapy drug used to treat acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and acute promyelocytic leukaemia (a rare form of AML). It may sometimes be used to treat other cancers.

Does mesalamine weaken immune system?

Mesalamine base drugs are safe and do not suppress the immune system. These include : Asacol, Delzicol, Colazal, Balsalazide, Pentasa, Salofalk, Lialda and Apriso. The overall infection risk is low.

What drugs compromise your immune system?

Other medicines which suppress the immune system include:

  • Azathioprine.
  • Mycophenolate mofetil.
  • Monoclonal antibodies – of which there are many ending in “mab”, such as bevacizumab, rituximab and trastuzumab.
  • Anti-TNF drugs such as etanercept, infliximab, adalimumab, certolizumab and golimumab. …
  • Methotrexate.
  • Ciclosporin.

What are the side effects of 6-mercaptopurine?


  • This medication belongs to a class of drugs called immunomodulators. …
  • Infrequently reported side effects may include headache, nausea, vomiting, diarrhea, tiredness, mouth sores, rash, fever, joint pain, low blood counts and anemia, and liver inflammation.

Can mercaptopurine cause weight gain?

Swelling of the body, tiredness, bruising. High blood pressure which may cause headaches, dizziness, blurred vision. Belly pain. Increased appetite and weight gain.

What time should I take mercaptopurine?

You can take Mercaptopurine with food or on an empty stomach but the choice of method should be consistent from day to day. You should take your medicine at least 1 hour before or 2 hours after having milk or dairy products.