Is TWINRIX vaccine a live vaccine?

Hepatitis B surface antigen3,4

What is in the TWINRIX vaccine?

Twinrix contains 720 ELISA units of inactivated hepatitis A virus and 20 mcg of recombinant HBsAg protein per ml. Twinrix should be administered by intramuscular injection. Do no inject intravenously or intradermal. In adults, the injection should be given in the deltoid region.

What are the side effects of TWINRIX vaccine?

Pain/redness/swelling at the injection site, fever, tiredness, headache, nausea, and diarrhea may occur. If any of these effects persist or worsen, tell your health care professional promptly.

How does the TWINRIX vaccine work?

TWINRIX is a combination vaccine used to prevent hepatitis A and hepatitis B infection. The vaccine works by causing the body to produce its own protection (antibodies) against these diseases. Hepatitis A and hepatitis B are infectious diseases, which cause the liver to be become inflamed (swollen).

Who should not get TWINRIX?

To avoid diagnostic confusion between manifestations of an acute illness and possible vaccine 60 adverse effects, vaccination with TWINRIX should be postponed in persons with moderate or 61 severe acute febrile illness unless they are at immediate risk of hepatitis A or hepatitis B 62 infection.

How long is the Twinrix vaccine good for?

When you complete the Twinrix® series,your protection will likely last for at least 20 years for hepatitis A and lifelong for hepatitis B. The best defense against germs is frequent hand washing; wash your hands with soap and water for at least 15 seconds or use alcohol-based hand sanitizers.

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Can twinrix cause liver damage?

In our patient, who had a previously unrecognized, clinically silent AIH with advanced liver fibrosis, the exposure to Twinrix® led to the development of severe jaundice and an acute, clinically overt exacerbation of chronic liver disease. No other case of AIH after vaccination has been reported yet.

Where is twinrix injection given?

Twinrix Adult is for intramuscular injection, preferably in the deltoid region. Exceptionally the vaccine may be administered subcutaneously in patients with thrombocytopenia or bleeding disorders.

Are 2 doses of Twinrix enough?

Dosing Schedules

It should be noted that two doses of the combined vaccine will protect almost 100% against HA but result in protective anti-HBs antibodies level in 50%–95% of individuals.

How much is the Twinrix vaccine?

Immunization Costs

DIN # Price
02230578 Twinrix $76.00 per dose
02237548 Twinrix Jr. $55.00 per dose
02130955 Typhoid Injection $44.00 per dose
02246081 Varicella $90.00 per dose

How long does Hep A and B vaccine last?

Moreover, the anti-HAV and anti-HBs titers in adults elicited by a combined hepatitis A and B vaccine have been shown to remain high for up to 6 years after vaccination [41].