Which glycoprotein is responsible for flu?


What are the two key glycoproteins found in the influenza virus?

Figure 2: Electron micrograph of influenza A virus particles. The genome of influenza A viruses consists of eight single-stranded RNA segments, and the viral particle has two major glycoproteins on its surface: hemagglutinin and neuraminidase.

Does influenza have glycoproteins?

Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus.

What is responsible for causing the flu?

What Causes the Flu? The flu is caused by influenza viruses that infect the nose, throat, and lungs. These viruses spread when people with flu cough, sneeze or talk, sending droplets with the virus into the air and potentially into the mouths or noses of people who are nearby.

Is Influenza an envelope virus?

Influenza viruses are members of the family Orthomyxoviridae. This family represents enveloped viruses the genome of which consists of segmented negative-sense single-strand RNA segments.

What shape is flu virus?

By electron microscopy, influenza A and B viruses are virtually indistinguishable. They are spherical or filamentous in shape, with the spherical forms on the order of 100 nm in diameter and the filamentous forms often in excess of 300 nm in length.

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What does neuraminidase do in influenza?

Drugs called neuraminidase inhibitors, which include oseltamivir (Tamiflu) and zanamivir (Relenza), inhibit the release of influenza A and B viruses from host cells. This inhibition stops the process of viral replication. Neuraminidase inhibitors are commonly used in both the prevention and the treatment of influenza.

Which stage of virus occurs first?

The first stage is entry. Entry involves attachment, in which a virus particle encounters the host cell and attaches to the cell surface, penetration, in which a virus particle reaches the cytoplasm, and uncoating, in which the virus sheds its capsid.

What are examples of glycoproteins?

Some of the examples where glycoproteins are found naturally:

  • collagen.
  • mucins.
  • transferrin.
  • ceruloplasmin.
  • immunoglobulins.
  • antibodies.
  • histocompatibility antigens.
  • hormones (e.g. follicle-stimulating hormone, luteinizing hormone, human chorionic gonadotropin, thyroid-stimulating hormone, erythropoietin, alpha-fetoprotein)