Membrane fusion mediated by hemagglutinin
What is the function of hemagglutinin spikes?
Hemagglutinin (HA) or Haemagglutinin (BE) is an antigenic glycoprotein found on the surface of the influenza viruses. It is responsible for binding the virus to the cell that is being infected.
What is the receptor for the influenza virus haemagglutinin?
Influenza haemagglutinin (HA) is a glycoprotein coded in the HA gene segment of the influenza virus and along with neuraminidase, is expressed as a trimer on the surface of the viral capsid.
What is the function of H spikes on an influenza virus?
H spikes are associated with hemagglutinin, a type of glycoprotein that assists the virus in identifying the receptors on the host cell.
What does hemagglutinin do in influenza?
The hemagglutinin glycoprotein of influenza virus has important functions in the initiation of infection: it mediates adsorption of the virus particles to cell surface receptors and is responsible for the subsequent uncoating of the virus by a process of fusion between viral and host membranes.
What protein does influenza bind to?
For influenza viruses, it has been known for a long time that the viral attachment protein, hemagglutinin (HA), binds to and uses sialic acid-containing molecules as receptors.
What is the function of the neuraminidase NA protein on the influenza flu virus?
An important function of the NA protein is to remove sialic acid from glycoproteins. Sialic acid is present on many cell surface proteins as well as on the viral glycoproteins; it is the cell receptor to which influenza virus attaches via the HA protein.
How do we name and identify influenza?
Influenza A viruses are classified by subtypes based on the properties of their hemagglutinin (H) and neuraminidase (N) surface proteins. There are 18 different HA subtypes and 11 different NA subtypes. Subtypes are named by combining the H and N numbers – e.g., A(H1N1), A(H3N2).
What disease does influenza cause?
Complications of flu can include bacterial pneumonia, ear infections, sinus infections and worsening of chronic medical conditions, such as congestive heart failure, asthma, or diabetes.
What is the life cycle of influenza virus?
The influenza virus life cycle can be divided into the following stages: entry into the host cell; entry of vRNPs into the nucleus; transcription and replication of the viral genome; export of the vRNPs from the nucleus; and assembly and budding at the host cell plasma membrane.